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DNA opening during transcription initiation by RNA polymerase II in atomic detail
RNA polymerase II (RNAP II) synthesizes RNA by reading the DNA code. During transcription initiation, RNAP II opens the double-stranded …
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DNA opening during transcription initiation by RNA polymerase II in atomic detail
Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap
Staphylococcus epidermidis is a commensal bacterium on human skin that is also the leading cause of medical device-related infections. …
Alexander E. Yarawsky, Jesse B. Hopkins, Leonie Chatzimagas, Jochen Hub, Andrew B. Herr
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Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap
Lipid Droplets Embedded in a Model Cell Membrane Create a Phospholipid Diffusion Barrier
Abstract Lipid droplets (LDs) are ubiquitous, cytoplasmic fat storage organelles that originate from the endoplasmic reticulum (ER) …
Sevde Puza, Stefanie Caesar, Chetan S Poojari, Michael Jung, Ralf Seemann, Jochen Hub, Bianca Schrul, Jean-Baptiste Fleury
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Lipid Droplets Embedded in a Model Cell Membrane Create a Phospholipid Diffusion Barrier
Free energies of membrane stalk formation from a lipidomics perspective
Many biological membranes are asymmetric and exhibit complex lipid composition, comprising hundreds of distinct chemical species. …
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Free energies of membrane stalk formation from a lipidomics perspective
Propensity, free energy contributions and conformation of primary n-alcohols at a water surface
Atmospheric aerosols contain organic molecules that serve as cloud condensation nucleation sites and affect the climate. Several …
Victor Ekholm, Carl Caleman, Jochen Hub, Malin Wohlert
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Propensity, free energy contributions and conformation of primary n-alcohols at a water surface
Structure and dynamics of the quaternary hunchback mRNA translation repression complex
A key regulatory process during Drosophila development is the localized suppression of the hunchback mRNA translation at the posterior, …
Jakub Macošek, Bernd Simon, Johanna Linse, Pravin Kumar Ankush Jagtap, Sophie L Winter, Jaelle Foot, Karine Lapouge, Kathryn Perez, Mandy Rettel, Miloš Ivanović, Pawel Masiewicz, Brice Murciano, Mikhail M Savitski, Inga Loedige, Jochen Hub, Frank Gabel, Janosch Hennig
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Structure and dynamics of the quaternary hunchback mRNA translation repression complex
Three- and four-site models for heavy water: SPC/E-HW, TIP3P-HW, and TIP4P/2005-HW
Heavy water or deuterium oxide, D2O, is used as a solvent in various biophysical and chemical experiments. To model such experiments …
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Three- and four-site models for heavy water: SPC/E-HW, TIP3P-HW, and TIP4P/2005-HW
The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation
The Src-homology-2 domain–containing phosphatase SHP2 is a critical regulator of signal transduction, being implicated in cell growth …
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The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation
The structure of Prp2 bound to RNA and ADP-BeF$_3$$^-$ reveals structural features important for RNA unwinding by DEAH-box ATPases
Noncoding intron sequences present in precursor mRNAs need to be removed prior to translation, and they are excised via the …
Florian Hamann, Lars C. Zimmerningkat, Robert Becker, Tim B. Garbers, Piotr Neumann, Jochen Hub, Ralf Ficner
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The structure of Prp2 bound to RNA and ADP-BeF$_3$$^-$ reveals structural features important for RNA unwinding by DEAH-box ATPases
How arginine derivatives alter the stability of lipid membranes: dissecting the roles of side chains, backbone and termini
Arginine (R)-rich peptides constitute the most relevant class of cell-penetrating peptides and other membrane-active peptides that can …
Sarah F. Verbeek, Neha Awasthi, Nikolas K. Teiwes, Ingo Mey, Jochen Hub, Andreas Janshoff
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How arginine derivatives alter the stability of lipid membranes: dissecting the roles of side chains, backbone and termini