2

Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
Proton translocation through lipid membranes is a fundamental process in the field of biology. Several theoretical models have been …
Seonwoo Lee, Chetan S Poojari, Anna Maznichenko, David Roesel, Iwona Swiderska, Peter Pohl, Jochen Hub, Sylvie Roke
PDF Cite DOI
Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements
Lipid droplet (LD) function relies on proteins partitioning between the endoplasmic reticulum (ER) phospholipid bilayer and the LD …
Ravi Dhiman, Rehani S. Perera, Chetan S Poojari, Haakon T. A. Wiedemann, Reinhard Kappl, Christopher W. M. Kay, Jochen Hub, Bianca Schrul
PDF Cite DOI
Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements
MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to physiological stress and metabolic challenges. …
John Reinhard, Leonhard Starke, Christian Klose, Per Haberkant, Henrik Hammarén, Frank Stein, Ofir Klein, Charlotte Berhorst, Heike Stumpf, James P. Sáenz, Jochen Hub, Maya Schuldiner, Robert Ernst
PDF Cite DOI bioRxiv
MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Molecular simulations reveal the free energy landscape and transition state of membrane electroporation
The formation of pores over lipid membranes by the application of electric fields, termed membrane electroporation, is widely used in …
PDF Cite DOI bioRxiv
Molecular simulations reveal the free energy landscape and transition state of membrane electroporation
Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet
SHP2 is a tyrosine phosphatase that plays a regulatory role in multiple intracellular signaling cascades and is known to be oncogenic …
Michelangelo Marasco, John Kirkpatrick, Teresa Carlomagno, Jochen Hub, Massimiliano Anselmi
PDF Cite DOI
Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet
Atomistic ensemble of active SHP2
SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause …
PDF Cite DOI Supplement 1 Supplement 2 bioRxiv
Atomistic ensemble of active SHP2
Scrutinizing the protein hydration shell from molecular dynamics simulations against consensus small-angle scattering data
Biological macromolecules in solution are surrounded by a hydration shell, whose structure differs from the structure of bulk solvent. …
PDF Cite DOI bioRxiv
Scrutinizing the protein hydration shell from molecular dynamics simulations against consensus small-angle scattering data
Molecular Simulations of Liquid Jet Explosions and Shock Waves Induced by X-Ray Free-Electron Lasers
X-ray free-electron lasers (XFELs) produce x-ray pulses with high brilliance and short pulse duration. These properties enable …
PDF Cite DOI Supplement arXiv
Molecular Simulations of Liquid Jet Explosions and Shock Waves Induced by X-Ray Free-Electron Lasers
Hydrophobin Bilayer as Water Impermeable Protein Membrane
One of the most important properties of membranes is their permeability to water and other small molecules. A targeted change in …
Friederike Nolle, Leonhard Starke, Alessandra Griffo, Michael Lienemann, Karin Jacobs, Ralf Seemann, Jean-Baptiste Fleury, Jochen Hub, Hendrik Hähl
PDF Cite DOI Supplement
Hydrophobin Bilayer as Water Impermeable Protein Membrane
Converging PMF Calculations of Antibiotic Permeation across an Outer Membrane Porin with Subkilocalorie per Mole Accuracy
The emergence of multidrug-resistant pathogens led to a critical need for new antibiotics. A key property of effective antibiotics …
PDF Cite DOI arXiv Supplement
Converging PMF Calculations of Antibiotic Permeation across an Outer Membrane Porin with Subkilocalorie per Mole Accuracy