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Structural basis of poxvirus fusion regulation and A16/G9 antibody mediated neutralization and protection
Monkeypox virus (MPXV) is a poxvirus endemic to Central and West Africa with high epidemic potential. Pox-viruses enter host cells via …
Annalisa Meola, Riccardo Vernuccio, Leandro Battini, Guillermo Albericio, Pilar Delgado, Rebecca BamFord, Laura Pokorny, Manon Broutin, Alejandro Martínez León, Sébastien Gallien, Maria Gil, Maria A. Noriega, Florence Guivel-Benhassine, Françoise Porrot, Jeanne Postal, Julian Buchrieser, Mathieu Hubert, Ahmed Haouz, Pierre Lafaye, Mariano Esteban, Jochen S. Hub, Matthieu Mahévas, Pascal Chappert, Jason Mercer, Juan Garcia-Arriaza, Olivier Schwartz, Pablo Guardado-Calvo
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Structural basis of poxvirus fusion regulation and A16/G9 antibody mediated neutralization and protection
Tau accelerates tubulin exchange in the microtubule lattice
Microtubules are cytoskeletal filaments that exhibit dynamic tip instability and, as recent discoveries reveal, possess a dynamic …
Subham Biswas, Rahul Grover, Cordula Reuther, Chetan S. Poojari, M. Reza Shaebani, Mona Grünewald, Amir Zablotsky, Jochen S. Hub, Stefan Diez, Karin John, Laura Schaedel
PDF DOI bioRxiv
Tau accelerates tubulin exchange in the microtubule lattice
Moldrug algorithm for an automated ligand binding site exploration by 3D aware molecular enumerations
We present Moldrug, a computational tool for accelerating the hit-to-lead phase in structure-based drug design. Moldrug explores the …
Alejandro Martínez León, Benjamin Ries, Jochen S. Hub, Aniket Magarkar
PDF Cite DOI ChemRxiv
Moldrug algorithm for an automated ligand binding site exploration by 3D aware molecular enumerations
Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes
Viral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The …
PDF Cite DOI bioRxiv
Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes
Structural insights into tecovirimat antiviral activity and poxvirus resistance
Mpox is a zoonotic disease endemic to Central and West Africa. Since 2022, two human-adapted monkeypox virus (MPXV) strains have caused …
Riccardo Vernuccio, Alejandro Martínez León, Chetan S. Poojari, Julian Buchrieser, Christopher Selverian, Yakin Jaleta, Annalisa Meola, Florence Guivel-Benhassine, Françoise Porrot, Ahmed Haouz, Maelenn Chevreuil, Bertrand Raynal, Jason Mercer, Etienne Simon-Loriere, Kartik Chandran, Olivier Schwartz, Jochen S. Hub, Pablo Guardado-Calvo
PDF Cite DOI ResearchSquare
Structural insights into tecovirimat antiviral activity and poxvirus resistance
How pore formation in complex biological membranes is governed by lipid composition, mechanics, and lateral sorting
The primary function of biological membranes is to enable compartmentalization among cells and organelles. Loss of integrity by the …
Leonhard Starke, Christoph Allolio, Jochen S. Hub
PDF Cite DOI bioRxiv
How pore formation in complex biological membranes is governed by lipid composition, mechanics, and lateral sorting
Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
Proton translocation through lipid membranes is a fundamental process in the field of biology. Several theoretical models have been …
Seonwoo Lee, Chetan S. Poojari, Anna Maznichenko, David Roesel, Iwona Swiderska, Peter Pohl, Jochen S. Hub, Sylvie Roke
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Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements
Lipid droplet (LD) function relies on proteins partitioning between the endoplasmic reticulum (ER) phospholipid bilayer and the LD …
Ravi Dhiman, Rehani S. Perera, Chetan S. Poojari, Haakon T. A. Wiedemann, Reinhard Kappl, Christopher W. M. Kay, Jochen S. Hub, Bianca Schrul
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Hairpin protein partitioning from the ER to lipid droplets involves major structural rearrangements
MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to physiological stress and metabolic challenges. …
John Reinhard, Leonhard Starke, Christian Klose, Per Haberkant, Henrik Hammarén, Frank Stein, Ofir Klein, Charlotte Berhorst, Heike Stumpf, James P. Sáenz, Jochen S. Hub, Maya Schuldiner, Robert Ernst
PDF Cite DOI bioRxiv
MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Molecular simulations reveal the free energy landscape and transition state of membrane electroporation
The formation of pores over lipid membranes by the application of electric fields, termed membrane electroporation, is widely used in …
PDF Cite DOI bioRxiv
Molecular simulations reveal the free energy landscape and transition state of membrane electroporation