Latest
- Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet
- Atomistic ensemble of active SHP2
- Revealing Allostery in PTPN11 SH2 Domains from MD Simulations
- Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains
- The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation
- An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
- Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase